altered plasma marker of oxidative dna damage and total antioxidant capacity in patients with alzheimer's disease
نویسندگان
چکیده
background: recent studies have shown that oxidative stress (os) is the most important indicator in the pathogenesis of alzheimer's disease (ad), but the results in previous studies are conflicting. this study aimed to assess the plasma levels of 8-hydroxy-2'-deoxyguanosine (8-ohdg) as dna oxidative damage marker and total antioxidant capacity (tac) in patients with ad versus control group. methods: thirty patients with ad and 30 sex-and age-matched healthy subjects were studied. diagnosis of ad was based on national institute of neurological and communicative disorders and stroke and the alzheimer's disease and related disorders association (nincds/adrda) criteria. also for the patients, mini-mental state examination (mmse), computed tomography (ct) scan and brain magnetic resonance imaging (mri) were done. plasma levels of 8-ohdg and tac were measured by competitive elisa method and ferric reducing antioxidant power (frap) assay, respectively. results: plasma levels of 8-ohdg was significantly higher in ad compared to control group (p<0.001), while the total antioxidant was significantly lower in patients compared to controls (p=0.002). the value of area under the roc curve for 8-ohdg and tac in discriminating ad from controls were 0.87 and 0.32, respectively. conclusion: our results indicate a link between oxidative stress and ad indicating a possible contributive role of these markers in the development of ad and as an indicator in the discrimination of ad from healthy controls.
منابع مشابه
Altered plasma marker of oxidative DNA damage and total antioxidant capacity in patients with Alzheimer\'s disease
Background: Recent studies have shown that oxidative stress (OS) is the most important indicator in the pathogenesis of Alzheimer's disease (AD), but the results in previous studies are conflicting. This study aimed to assess the plasma levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as DNA oxidative damage marker and total antioxidant capacity (TAC) in patients with AD versus control group. ...
متن کاملAltered plasma marker of oxidative DNA damage and total antioxidant capacity in patients with Alzheimer's disease
BACKGROUND Recent studies have shown that oxidative stress (OS) is the most important indicator in the pathogenesis of Alzheimer's disease (AD), but the results in previous studies are conflicting. This study aimed to assess the plasma levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as DNA oxidative damage marker and total antioxidant capacity (TAC) in patients with AD versus control group. ME...
متن کاملOxidative DNA damage and total antioxidant status in glaucoma patients
PURPOSE To evaluate DNA damage markers and the antioxidant status of serum and aqueous humor in glaucoma patients. METHODS Aqueous humor and serum samples were obtained at the time of surgery from 28 patients with glaucoma and 27 patients with cataracts. Total antioxidant status (TAS) and 8-hydroxy-2´-deoxyguanosine (8-OHdG) levels of all samples were determined by spectrophotometric and enzy...
متن کاملRelationship between Dietary Total Antioxidant Capacity and Oxidative Stress Markers in Patients with Knee Osteoarthritis
Background and purpose: Considering the pathologic importance of oxidative stress in osteoarthritis (OA), this study aimed to investigate the association between dietary total antioxidant capacity (DTAC) and oxidative stress markers in patients with knee OA. Materials and methods: In a cross-sectional study, dietary intakes of 152 patients with knee OA attending health centers in Zabol, Iran (...
متن کاملEffects of Regular Treadmill Exercise on a DNA Oxidative-Damage Marker and Total Antioxidant Capacity in Rat Hippocampal Tissue
BACKGROUND AND PURPOSE Regular exercise can result in changes in the levels of oxidative stress in the hippocampus; however, little attention has been paid to physical-activity-induced neuronal protection to exposure to lead compounds. This study investigated the effects of regular treadmill exercise on a DNA oxidative-damage marker [8-hydroxy-2'-deoxyguanosine (8-OHdG)] and the total antioxida...
متن کاملAssociation of Uric Acid with Antioxidant Capacity of Plasma in Patients with Type 2 Diabetic Nephropathy
Background: The role of attenuation in antioxidant capacity or expansion of pro-oxidant/oxidant is well known for the development of stress oxidative. The aim of this study was to evaluate the plasma antioxidant capacity along with uric acid in patients with diabetic nephropathy (DN+) and without diabetic nephropathy (DN-). Materials and Methods: The research population included 88 patients ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
caspian journal of internal medicineجلد ۷، شماره ۲، صفحات ۸۸-۹۲
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023